- Provides clinically effective high doses of vitamins D per capsule to achieve optimal serum levels
- Optimal form of vitamin D: D3 has greater potency than D2 for increasing serum and storage levels of vitamin D
- In a base of organic flaxseed oil for improved intestinal absorption
- Easy to swallow and highly bioavailable softgel
The evidence for vitamin D’s importance continues to grow, documenting both widespread insufficiency as well as therapeutic efficacy. Vitamin D receptors are linked to chromosomes in nearly every cell and tissue, with diverse and organ-specific effects. Vitamin D has both hormonal and non-hormonal functions, with the ubiquity of vitamin D receptors translating into a myriad of physiological actions, ranging from bone metabolism to modulation of immune activity. It regulates the expression of hundreds of genes, influences cellular proliferation and signaling, insulin production and sensitivity, and is a critical inhibitor of several inflammatory pathways. Lower levels have now been associated with a higher incidence of both acute and chronic illness, including autoimmune disease, cardiovascular disease, cancer, diabetes, hypertension, infertility, and overall mortality rates. All-cause mortality is the lowest in those with 25-OH vitamin D levels between 75 to 112.5 nmol/L, in many cases requiring high doses to achieve, also true for those with genetic variants. A dose of nearly 10,000 IU was needed to achieve levels in this optimal range for 98% of individuals in a community based study of nearly 4000.