• Kavinace 60c

    NeuroScience Inc

    Item #:
  • $50.00

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Description

Kavinace 60c

Contains a blend of ingredients involved in the synthesis and activity of GABA, a neurotransmitter important for sleep*

GABA is the primary inhibitory neurotransmitter in the brain, meaning its central role is to balance excitability of neurons (1). Because of its function, GABA is important for promoting sleep, calm, and managing stress (2-4). Stress is thought to alter GABA synthesis and activity by affecting the expression of GABA-synthesizing enzymes and receptors (5).

Ingredients such as taurine and vitamin B6 are important for glutamate-GABA balance.* High glutamate can damage neurons, alter cellular homeostasis, and cause mitochondrial dysfunction, which can ultimately lead to cell death (6). Taurine demonstrates GABA-A agonist activity and protects neurons and mitochondria against glutamate-induced damage (6, 7).* Active form of vitamin B6 is important for the synthesis of GABA as it is a required cofactor for glutamate decarboxylase, the enzyme responsible for converting glutamate to GABA (8-10).*

References:

  1. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
  2. Mohler H. Neuropharmacology. 2012;62(1):42-53.
  3. Saper C, et al. Nature. 2005;437(7063):1257-63.
  4. Mody I and Maguire J. Front Cell Neurosci. 2012;6:4.
  5. Maguire J. Front Cell Neurosci. 2014;8:157.
  6. Ye H, et al. Can J Neurol Sci. 2013;40(5):628-34.
  7. Kletke O, et al. PLoS One. 2013;8(4):e61733.
  8. Rowley N, et al. Neurochem Int. 2012;61(4):546-58.
  9. Martin D. Cell Mol Neurobiol. 1987;7(3):237-53.
  10. Mukherjee T, et al. Biochim Biophys Acta. 2011;1814(11):1585-96

Servings Per Container: 30

Serving Size: 2 Capsules

Amount Per Serving:

Vitamin B6 ... 2mg (as pyridoxine HCl & pyridoxal 5-phosphate)

Prorietary Blend ... 950mg

Taurine and 4-amino-3-phenylbutyric acid HCl

Other Ingredients:

Microcrystalline Cellulose, Vegetable Cellulos(vegetarian capsules), and Magnesium Stearate.

Contain no:

Gluten, corn, soy, salt, sucrose, starch, yeast, artificial flavors, or artificial colors.

Take 1-2 capsules one to two times daily. Do not exceed 6 capsules in one day.

Warning:

Consult a health professional before taking this or any other product.

Consult your physician for more information.

Caution:

Keep out of reach of children. Store in a cool, dry place. Safety-sealed for your protection and for product freshness. Do not use if seal is missing or broken

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.