• EstroVantage EM 90c

    Bioclinic Naturals

    Item #:
  • $45.00 $50.00

  • Share this product


In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17-estradiol. In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16a-hydroxyestrone (16a-OHE1). Both 16a-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16a-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative. As such, an increased ratio 2-OHE:16a-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women. Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events. Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption. It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.


- IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.

- In a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (Rosemarinus officinalis), were found to be a promising adjuvant therapy in advanced breast cancer patients

- Green tea polyphenols inhibit the proliferation of breast cancer cells in vivo and in vitro

- Silymarin can down-regulate gene products involved in the proliferation of tumor cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules)

- Curcumin inhibits human breast cancer cell growth by mediating certain signaling cascades including the modulation of the NF-kB signaling pathway

- Sulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression

- Standardized extracts

Servings Per Container: 30

Serving Size: 3 capsules

Amount Per Serving

Calcium D-Glucarate .... 225 mg

(d-glucaric acid calcium salt)

Indole-3-Carbinol .... 225 mg


Green Tea Extract .... 150 mg

(Camellia sinensis) (leaf) (80% catchins, 45%EGCg<1% caffeine)

Tomato Extract .... 150 mg

(Lycopersicon esculentum) (fruit) (5% lycopene)

Broccoli Powder .... 83 mg

(Brassica oleracea var. italica) (aerial) (0.36% sulforaphane)

Turmeric Extract .... 75 mg

(Curcuma longa) (root) (95% curcuminoids)

Milk Thistle Extract .... 75 mg

(Silybum marianum) (seed) (60% silymarin)

DIM .... 75 mg

(3, 3-diindolylmethane)

Rosemary Extract .... 38 mg

(Rosmarinus officinalis) (leaf)

Other Ingredients:

Vegetarian capsule (Carbohydrate gum (cellulose), purified water), microcrystalline cellulose and magnesium stearate (vegetable grade).

Take 3 capsules per day taken with food or as directed by a health care professional. Consult a health care professional for use beyond 12 weeks.


Consult a health professional before taking this or any other product.

Consult your physician for more information.


Keep out of reach of children. Store in a cool, dry place. Safety-sealed for your protection and for product freshness. Do not use if seal is missing or broken

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.